Tofacitinib CAS: 477600-75-2 Onye na-ebuputa ihe.

Tofacitinib bụ ọgwụ maka ọgwụgwọ ọrịa ogbu na nkwonkwo (RA), psoriasis, ọrịa bowel na-egbuke egbuke, na ọrịa ndị ọzọ na-adịghị ahụkebe, yana maka igbochi nkwụsị nke akụkụ ahụ.Ọ bụ ihe mgbochi nke enzyme Janus kinase 3 (JAK3), nke pụtara na ọ na-egbochi ụzọ akara JAK-STAT nke na-ebufe ozi n'èzí cell n'ime mkpụrụ ndụ cell, na-emetụta nsụgharị DNA.N'oge na-adịbeghị anya, e gosipụtara ya na ụdị murine nke ọrịa ogbu na nkwonkwo guzosie ike, tofacitinib na-emeziwanye ọrịa ngwa ngwa site n'igbochi mmepụta nke ndị mgbasa ozi mkpali na igbochi STAT1 na-adabere na mkpụrụ ndụ ihe nketa na nkwonkwo anụ ahụ. Nke a dị irè na ụdị ọrịa a jikọtara ya na nkwụsị nke ma JAK1 na 3 akara ngosi. ụzọ, na-atụ aro na tofacitinib nwere ike nweta uru ọgwụgwọ site na ụzọ ndị na-abụghị nanị na mgbochi nke JAK3.