β-Nicotinamide Adenine Dinucleotide CAS:53-84-9

NAD+ dị oke mkpa na ọrụ sel ma enwetala mmasị n'ọhịa dịka nyocha ịka nká, metabolism, na ahụike sel. Dịka coenzyme, NAD+ na-etinye aka na mmeghachi omume redox dị mkpa maka mmepụta ike n'ime mitochondria, na-akwado usoro dịka glycolysis, okirikiri tricarboxylic acid, na oxidative phosphorylation. Na mgbakwunye, NAD+ na-eje ozi dị ka ihe ndabere maka enzymes dị ka sirtuins na PARPs, bụ ndị na-etinye aka na ndozi DNA, nhazi ngosipụta mkpụrụ ndụ ihe nketa, na ụzọ nzaghachi nrụgide sel. N'afọ ndị na-adịbeghị anya, ihe ndị na-ebute NAD+, dị ka nicotinamide riboside (NR) na nicotinamide mononucleotide (NMN), enwetala nlebara anya dị ka ihe mgbakwunye nwere ike ịkwado ọkwa NAD+ n'ime sel. Nnyocha na-egosi na ịnọgide na-enwe ọkwa NAD+ kacha mma nwere ike ịrụ ọrụ na mitochondrial biogenesis, metabolic homeostasis, na ogologo ndụ. N'ihi ya, a na-enyocha ihe ndị na-ebute NAD+ maka ikike ha nwere ibelata mbelata metụtara afọ, kwado ịka nká dị mma, na idozi enweghị nguzozi metabolic metụtara ọnọdụ dị ka oke ibu na ọrịa shuga. Ọzọkwa, NAD+ bụ mpaghara nke mmasị na-eto eto na physiology egwuregwu na mmega ahụ n'ihi itinye aka ya na metabolism ike na ọrụ mitochondrial. Ọmụmụ ihe ndị na-enyocha mgbanwe NAD+ n'ihe gbasara arụmọrụ mmega ahụ, mgbake akwara, na ikike ntachi obi ka na-aga n'ihu, yana mmetụta nwere ike inwe na arụmọrụ egwuregwu na iguzogide anụ ahụ. N'ozuzu, NAD+ na ihe ndị bu ya ụzọ na-anọchite anya mpaghara nyocha sayensị na-arụ ọrụ nke nwere ike itinye n'ọrụ gbasara ịka nká, ahụike sel, metabolism, na physiology mmega ahụ, na-egosi nnukwu ma na-agbanwe agbanwe nke nyocha na mkpa ọgwụgwọ nwere ike ịdị.