Acetylcholinesterase CAS:9000-81-1

Mmetụta anticholinesterase na-ezo aka n'ike ụfọdụ ọgwụ ma ọ bụ kemịkalụ nwere igbochi ọrụ nke enzyme acetylcholinesterase. Acetylcholinesterase bụ ihe na-akpata imebi acetylcholine neurotransmitter dị n'ahụ. Site na igbochi enzyme a, anticholinesterases na-eme ka ọkwa acetylcholine dịkwuo elu, na-eduga na mmụba nke ọrụ cholinergic.

Isi ihe a na-eji anticholinesterases eme bụ ịgwọ ọrịa ndị a na-eji mbelata ọrụ cholinergic. Ndị a gụnyere nsogbu akwara ozi dịka ọrịa Alzheimer na myasthenia gravis. Na ọrịa Alzheimer, a na-eji anticholinesterases dịka donepezil, rivastigmine, na galantamine egbochi mmebi nke acetylcholine ma mee ka ọrụ akwara cholinergic dịkwuo mma. Nke a nwere ike inyere aka melite ọrụ nghọta ma nwee ike ibelata ọganihu nke ọrịa ahụ.

Na myasthenia gravis, a na-eji anticholinesterases dịka neostigmine na pyridostigmine eme ka nnyefe akwara dịkwuo mma. Ọgwụ ndị a na-egbochi acetylcholinesterase ma na-eme ka ọkwa acetylcholine dịkwuo elu na njikọ akwara, na-eme ka akwara dịkwuo mma ma na-ebelata adịghị ike akwara.

Ọgwụ anticholinesterase nwekwara ike inyere aka ịchọpụta ma gwọọ ọrịa n'ihe gbasara nsị anticholinergic. Ọgwụ anticholinergic, dịka ụfọdụ ọgwụ nje ma ọ bụ ihe ndị na-akpata akwara, nwere ike ibute oke mgbochi cholinergic nke na-eduga na mgbaàmà dịka mgbagwoju anya, obi ngwa ngwa, ọnụ kpọrọ nkụ, na ọhụụ na-adịghị mma. N'ọnọdụ ndị dị otú a, enwere ike iji ọgwụ anticholinesterases dị ka pralidoxime gbanwee mmetụta ya site n'ịbawanye ọkwa acetylcholine ma na-asọmpi na ihe ndị na-egbu egbu.