Glucose-6-Fosphate Dehydrogenase CAS:9001-40-5

Metabolism nke sel: G6PD na-etinye aka na usoro metabolism glucose, ọkachasị ụzọ pentose phosphate. Ọ na-akwalite mgbanwe nke glucose-6-phosphate ka ọ bụrụ 6-phosphogluconolactone, na-emepụta NADPH n'ime usoro ahụ. NADPH bụ molekul dị mkpa maka usoro sel dị iche iche, gụnyere nchekwa antioxidant, biosynthesis nke abụba asịd na cholesterol, na ịnọgide na-enwe nguzozi redox cell.

Nchedo Antioxidant: NADPH nke G6PD mepụtara dị oke mkpa maka mmepụta nke glutathione belatara (GSH), molekul antioxidant dị mkpa. GSH na-echebe mkpụrụ ndụ site na nrụgide oxidative site na igbochi radicals free na ụdị oxygen reactive (ROS). Enweghị G6PD nwere ike imebi nnweta NADPH ma belata arụmọrụ nke nchekwa antioxidant, na-eduga na mmụba nke nnabata maka mmebi oxidative.

Ọrịa ọbara ọbara: Enweghị G6PD bụ ụkọ enzyme kachasị na-emetụta ụmụ nwoke n'ụwa niile. Ọ na-emetụtakarị ụmụ nwoke ma nwee ike ibute ọrịa ọbara ọbara, nke bụ ọnọdụ nke mbibi nke mkpụrụ ndụ ọbara uhie na-egosi. Ụfọdụ ihe na-akpata ya, dịka ọrịa, ụfọdụ ọgwụ (dịka ọmụmaatụ, ọgwụ mgbochi ịba, ọgwụ sulfa), na ụfọdụ nri (dịka ọmụmaatụ, agwa fava), nwere ike ibute hemolysis n'ime ndị nwere ụkọ G6PD. Enweghị ya na-akpata enweghị ike ijikwa nrụgide oxidative nke ihe ndị a na-akpata, na-ebute mmebi nke mkpụrụ ndụ ọbara uhie.

Ọgwụ Ọgwụ: Nnyocha G6PD dị mkpa n'ọgwụ ọgwụ iji gbochie mmeghachi omume ọjọọ nke ọgwụ. Ụfọdụ ọgwụ, dị ka ụfọdụ ọgwụ mgbochi ịba (dịka ọmụmaatụ, primaquine) na ọgwụ nje (dịka ọmụmaatụ, sulfonamides), nwere ike ibute hemolysis n'ime ndị nwere enweghị G6PD. Nnyocha mbụ maka enweghị G6PD na-enyere aka n'ịchọpụta ndị nọ n'ihe ize ndụ ma nwee ike iduzi nhọrọ nke ọgwụ ma ọ bụ iji ọgwụgwọ ọzọ iji gbochie nnukwu nsogbu hemolytic.