L-Lactate dehydrogenase CAS:9001-60-9

Mmetụta nke L-Lactate dehydrogenase (LDH) gụnyere ọrụ ya na metabolism ike sel na itinye aka ya na ntụgharị pyruvate ka ọ bụrụ lactate. LDH na-enyere aka idobe nguzozi ike na sel site n'inyere aka ịgbanwe pyruvate, ihe sitere na metabolism glucose, ka ọ bụrụ lactate. Usoro a, nke a maara dị ka anaerobic glycolysis, na-eme mgbe ikuku oxygen pere mpe.

LDH na-arụkwa ọrụ dị oke mkpa n'imegharị lactate. N'oge mmega ahụ siri ike ma ọ bụ mgbe ikuku oxygen dị ala, lactate nwere ike ịgbakọ n'ime anụ ahụ. LDH na-enyere aka imegharị lactate site n'ịgbanwe ya ka ọ bụrụ pyruvate, nke enwere ike iji dị ka ihe ndabere maka mmepụta ike ma ọ bụ gbanwee ka ọ bụrụ glucose site na gluconeogenesis. Usoro imegharị lactate a na-enye mkpụrụ ndụ ohere iji lactate nke ọma dị ka isi iyi ike ma na-enyere aka igbochi mmụba nke lactate, nke nwere ike imebi ọrụ sel.

LDH nwere ọtụtụ ojiji n'ọhịa ahụike. Otu n'ime ihe ndị bụ isi e ji ya eme bụ ihe nrịbama nchọpụta maka ụfọdụ ọrịa. Ọkwa LDH dị elu n'ọbara nwere ike igosi mmebi anụ ahụ ma ọ bụ ọnụnọ nke ọrịa dịka mmebi imeju, myocardial infarction, na ụfọdụ ụdị kansa. A na-enyocha ọkwa LDH mgbe niile n'ebe a na-agwọ ọrịa iji chọpụta ọganihu ọrịa na nzaghachi nye ọgwụgwọ.