Acetyl Octapeptide-3 CAS: 868844-74-0 usoro na ojiji

Acetyl Octapeptide-3 (CAS 868844-74-0) bụ peptide a ma ama na sayensị ịchọ mma, nke a na-erekarị n'aha azụmaahịa SNAP-8. Ka anyị kọwaa usoro ya na ojiji ya nke ọma.

1. Njirimara na Usoro nke Ọrụ

· Njirimara Kemịkalụ:Ọ bụ peptide sịntetik acetylated nke nwere usoro Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2. Acetylation ahụ na-eme ka akpụkpọ ahụ banye n'ime ma kwụsie ike.

· Usoro Isi:A na-akpọkarị ya "ihe ọzọ Botox nke dị n'elu," ihe ọ na-eme dabere na mgbochi asọmpi. Ọ na-eṅomi njedebe N-terminal nke protein SNAP-25, ihe dị mkpa na mgbagwoju anya SNARE dị mkpa maka ntọhapụ nke neurotransmitters (dị ka acetylcholine) nke na-egosi mkpụkọ akwara.

· Mmetụta Dị Mkpa:Site n'ịsọ mpi na SNAP-25 eke maka ebe dị na SNARE complex, ọ na-egbochi ịmepụta complex zuru oke. Nke a na-eme ka mwepụta neurotransmitter belata ntakịrị, na-eduga na mbelata na ike na ugboro ugboro nke mkpụkọ akwara ihu dị elu, si otú a na-eme ka ọdịdị nke ahịrị ngosipụta dị nro, karịsịa n'egedege ihu na gburugburu anya.

2. Ntuziaka Nhazi

Acetyl Octapeptide-3 bụ ihe dị ike mana dị nro. Usoro nhazi kwesịrị ekwesị dị oke mkpa maka nkwụsi ike na arụmọrụ.

A) Ntinye uche akwadoro:

· Ọkwa ojiji nkịtị dị n'etiti2% ruo 10%nke ngwọta peptide a gwakọtara agwakọta.

· A na-ejikarị ihe dị n'ime ihe e ji emepụta peptide (nke a na-akpọkarị ntụ ntụ ọcha nke e ji lyophilized mee) eme ihe. Ndị na-ere ahịa nkịtị na-enye ya dị ka2% ma ọ bụ 5%ihe ngwọta agbazere tupu oge eruo (n'ime mmiri ma ọ bụ ngwakọta mmiri/glycerin) maka nhazi dị mfe.

· Ntinye ikpeazụ nke peptide na-arụ ọrụ na ngwaahịa ikpeazụ na-abụkarị site na0.0005% ruo 0.002% (5-20 ppm)Na-agbaso ndụmọdụ ndị dọkịta nyere gị gbasara otu esi eji ya mgbe niile.

B) Ịgbaze na Ụgbọala:

· Ọ na-agbaze nke ukwuu n'ime mmiri. Ọ kacha mma ka e jiri ya mee ihe n'oge mmiri dị n'ime ngwaahịa.

· Ụgbọala kwesịrị ekwesị gụnyere:

· Serums (nke a na-ahụkarị)

· Gel

· Ude na ude mmiri (a ga-etinyerịrị ya n'ime mmiri tupu emulsion emee ya)

· Mmanụ Hydrophilic

· Ngwọta Ndị A Na-agba Fesa

C) pH na nkwụsi ike:

· Oke pH kacha mma:5.0 – 7.0Nhazi n'ime oke a na-eme ka kemịkalụ kwụsie ike ma kwekọọ na akpụkpọ ahụ.

· Zere gburugburu ebe nwere nnukwu acid (pH < 4) ma ọ bụ alkaline (pH > 8) ruo ogologo oge.

D) Okpomọkụ na Nhazi:

· Mmetụta okpomọkụ. Iji gbochie mmebi:

· Tinye na mmiri ahụ n'oge ma ọ bụ n'okpuru ya40°C (104°F).

· Ebe kacha mma itinye ya bụ mgbe emulsion ahụ jụrụ oyi ruo n'okpuru 40°C, ma ọ bụ gbazee ya na mmiri okpomọkụ ụlọ maka serum/gels.

· Zere nhazi okpomọkụ dị elu dị ka ijuputa ọkụ ma ọ bụrụ na data kwụsiri ike akwado ya.

E) Ndakọrịta na Ngwakọta Njikọta:

· Ọ dị mma nke ukwuu na: Peptides ndị ọzọ na-egbochi ịka nká (dịka ọmụmaatụ, Matrixyl, Argireline), hyaluronic acid, niacinamide, antioxidants (Vitamin C & E), ihe na-eme ka mmiri dị ọcha.

· Njikọta Ndị Na-arụkọ Ọrụ:

· Site na peptides ndị ọzọ na-agbanwe agbanwe: A na-ejikọkarị ya na Acetyl Hexapeptide-8 (Argireline) maka mmetụta mgbochi sara mbara, nke nwere ọtụtụ ebumnuche.

· Site na peptides na-eme ka collagen dịkwuo mma: Ijikọta ya na peptides dịka Palmitoyl Tripeptide-1 ma ọ bụ Matrixyl na-edozi ma ahịrị ndị na-agbanwe agbanwe (site na mmegharị akwara) na ahịrị ndị na-agbanwe agbanwe (site na mfu nke nkwado nhazi).

· Zere: Ihe ndị na-eme ka oxidation ma ọ bụ belata ihe ndị na-eme ka ọ dị ike. Kpachara anya na ụfọdụ ihe ndị nwere ike imetụta otú o si agbaze ma ọ bụ otú o si agbaze.

F) Nchekwa:

· Dịka ihe na-agbaze mmiri, usoro ikpeazụ chọrọ usoro nchekwa siri ike iji gbochie uto nje bacteria nke nwere ike imebi peptide ahụ.