Letrozole bụ akụkụ nke ọgbọ ọhụrụ nke ndị na-eme ihe mgbochi aromatase na-ahọrọ nke ọma ma bụrụ ihe na-emepụta benzotriazole na-emepụta ihe na artificially.Letrozole na-egbochi aromatase iji belata ọkwa estrogen, si otú a na-egbochi estrogen site na-akpali uto tumor.Ọrụ ya na vivo siri ike ugboro 150-250 karịa nke ọgbọ mbụ aromatase inhibitor Amarante.Dị ka ọ na-ahọrọ nke ukwuu, ọ gaghị emetụta glucocorticoid, mineralocorticoid na thyroid ọrụ;ọbụlagodi na nnukwu doses, ọ gaghị enwe mmetụta ọ bụla na-egbochi ihe nzuzo corticosteroid adrenal, na-enye ya nchịkọta ọgwụgwọ dị elu.