Tritylolmesartanethylester CAS:144690-33-5

Tritylolmesartanethylester dị oke mkpa na kemistri ọgwụ na nchọpụta ọgwụ, ọkachasị na mmepe nke ndị na-emegide ndị na-anabata angiotensin II nwere profaịlụ ọgwụ emelitere. Dịka ihe sitere na ọgwụ mgbochi ọbara mgbali elu a ma ama nke olmesartan medoxomil, ngwakọta a na-eje ozi dị ka ihe ndabere bara uru maka njikọta na nyocha nke analogues ọhụrụ nwere arụmọrụ ka mma na akụrụngwa pharmacokinetic. Na nyocha ọgwụ, a na-amụ Tritylolmesartanethylester maka ikike ya ịhazi sistemụ renin-angiotensin, nke na-arụ ọrụ dị mkpa n'ịchịkwa ọbara mgbali elu, nguzozi mmiri, na ọrụ obi. Site na inyocha mmekọrịta ya na ndị na-anabata angiotensin II, ndị nchọpụta na-achọ ịmepụta ogige ọhụrụ nke nwere ike igbochi mmetụta physiological nke angiotensin II nke ọma, na-eduga na mmepe nke ọgwụ mgbochi ọbara mgbali elu ọgbọ na-esote yana nsonaazụ ọgwụgwọ ka mma yana mbelata mmetụta ọjọọ. Ọzọkwa, mgbanwe nhazi na nyocha ọgwụ nke Tritylolmesartanethylester na analogues ya na-enye aka na nghọta nke mmekọrịta nhazi-ọrụ (SAR) n'ime klas ndị na-emegide ndị na-anabata angiotensin. Ihe ọmụma a na-eduzi nhazi ezi uche nke ndị na-eji ọgwụ eme ihe nke ọma site na njikọta nke ndị na-anabata ihe, nhọrọ, na nkwụsi ike metabolic, na-eme ka ụzọ dị mma maka ọganihu n'ọgwụgwọ ọrịa obi dịka ọbara mgbali elu, nkụda obi, na ọrịa shuga nephropathy. Ọzọkwa, ojiji Tritylolmesartanethylester nwere ike ịgbatị na ọmụmụ ihe tupu oge eruo iji kọwaa profaịlụ pharmacokinetic na pharmacodynamic ya, profaịlụ nsị, na ikike ọgwụgwọ site na nnwale in vitro na in vivo. Nnyocha ndị a na-enye data dị mkpa maka inyocha nchekwa na arụmọrụ ya, na-akwado ọganihu ya na nnwale ahụike na mmepe ọgwụ nwere ike. Na nchịkọta, ojiji Tritylolmesartanethylester gụnyere ọrụ dị mkpa ya na kemistri ọgwụ na nyocha ọgwụ dị ka ikpo okwu maka imewe, mmepụta, na nyocha nke ndị na-emegide angiotensin II receptor ọhụrụ, na-enye aka na ọganihu nke ọgwụgwọ antihypertensive na ọgwụ obi.