Uridine-5′-diphosphoglucuronic acid trisodium nnu CAS:63700-19-6

Mwepụ ihe mkpofu: UDP-glucuronic acid bụ molekul dị mkpa nke na-etinye aka na mmeghachi omume biotransformation nke phase II nke xenobiotics na ihe ndị dị n'ime ahụ. Ọ na-arụ ọrụ dị ka ihe na-ebute ụzọ maka mmepụta nke glucuronides, nke bụ conjugates na-agbaze nke ukwuu nke enwere ike iwepụ ngwa ngwa n'ahụ. Usoro mwepụ ihe mkpofu a na-enyere aka iwepụ ma wepụ ihe ndị nwere ike imerụ ahụ, dị ka ọgwụ, nsí gburugburu ebe obibi, na ụfọdụ ihe ndị sitere na metabolic.

Mgbanwe ọgwụ: Ọtụtụ ọgwụ na-enweta glucuronidation, usoro nke UDP-glucuronic acid na-ejikọta na molekul ọgwụ ahụ, na-ebute mmepụta nke glucuronide metabolite. Mmeghachi omume glucuronidation a na-emekarị ka mwepụ ọgwụ dị n'ahụ dịkwuo mma ma na-eme ka mwepụ ha dị mfe site na mmamịrị ma ọ bụ bile. A na-ejikarị nnu UDP-glucuronic acid trisodium eme ihe n'ọmụmụ ihe ndị na-enyocha metabolism na pharmacokinetics nke ọgwụ.

Ngwa nyocha: A na-eji nnu UDP-glucuronic acid trisodium eme ihe nke ukwuu dị ka ngwa nyocha n'ọtụtụ ọmụmụ metụtara metabolism ọgwụ, enzymology, na toxicology. Ọ na-enye isi iyi nke UDP-glucuronic acid maka nnwale in vitro ma na-enye ndị nchọpụta ohere inyocha mmetụta nke glucuronidation na mwepụ ọgwụ, bioavailability, na mmekọrịta ọgwụ na ọgwụ nwere ike inwe.

Glycosylation: UDP-glucuronic acid na-etinyekwa aka na mmeghachi omume glycosylation, ebe ọ na-arụ ọrụ dị ka onye na-enye glucuronic acid moieties maka mmepụta nke glycosaminoglycans (GAGs) na proteoglycans. Mkpụrụ ndụ ndị a nwere ọrụ dị mkpa na usoro dị iche iche nke ndụ, gụnyere njikọta sel, nhazi matrix extracellular, na mgbaàmà.