Leflunomide CAS: 75706-12-6 Onye nrụpụta ihe atụpụtara onyonyo.

Leflunomide CAS: 75706-12-6 Onye na-ebupụta ihe

Leflunomide bụ ọgwụ na-eme ka ọrịa na-agbanwe ọnụ na-enweta ya ma malite ya dị ka Arava na US maka ọgwụgwọ ọrịa ogbu na nkwonkwo (RA);ọ bụ nke mbụ na naanị ọgwụ a ga-egosi iji belata mmebi nkwonkwo nhazi nke RA, n'ihi ya, na-egbo mkpa ahụike na-enweghị ike.Leflunomide bụ pro-ọgwụ nke na-eme ngwa ngwa na nke fọrọ nke nta ka ọ bụrụ kpamkpam metabolized (ọkara ndụ, <60 nkeji) na-esote ọnụ. nchịkwa na teriflunomide, ọgwụ na-arụ ọrụ α-cyanoenol metabolite.

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Ngwa na Mmetụta

Leflunomide adịghị arụ ọrụ, mana teriflunomide na-egbochi njikọ pyrimidine de novo na usoro ọgwụgwọ dị ala site na igbochi dihydroorotate dehydrogenase (ọnụego na-ekpebi enzyme maka njikọ nke UMP), na-ebelata DNA na RNA njikọ, na ijide usoro mgbasawanye cell na mmepụta nke ọgwụ nje.Mbelata dihydroorotate na orotate na-eme n'otu oge na mbelata cofactor ya, ubiquinone (coenzyme Q).Mgbochi nke dihydroorotate dehydrogenase site na teriflunomide na-egosiputa kinetics enweghị asọmpi na enweghị asọmpi.Nlekọta nke leflunomide n'ime ndị ọrịa nwere ọrịa ogbu na nkwonkwo na-ebute mwepụ nke mkpụrụ ndụ B na-aga n'ihu na nhazi nke usoro ahụ ji alụso ọrịa ọgụ.

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Ihe mejupụtara	C12H9F3N2O2
Nyocha	99%
Ọdịdị	Ọcha ntụ ntụ
CAS Mba.	75706-12-6
Nkwakọ ngwaahịa	25KG
Ndụ shelf	afọ 2
Nchekwa	Chekwaa na ebe dị jụụ na nke akọrọ
Asambodo	ISO.